Updates and Opinions in Diagnosis and Treatment of Clostridiodes difficile in Pediatrics.
Sanchi MalhotraSindhu MohandasPublished in: Current treatment options in pediatrics (2021)
infection in pediatrics remain challenging and recommendations lag behind advances made in the adult field. Recent data suggests that use of fidaxomicin both as treatment of first episode or recurrences may be beneficial in pediatrics just as in adults. At an experienced center, FMT is associated with high cure rates. Bezlotuxumab a monoclonal antibody to toxin B that is already recommended for use in adults is being studied in children and should be available for clinical use soon. Oral vancomycin prophylaxis is also an emerging strategy for high-risk patients. Finally, a possible vaccine may be on the horizon for pediatrics.
Keyphrases
- monoclonal antibody
- end stage renal disease
- clostridium difficile
- ejection fraction
- newly diagnosed
- escherichia coli
- chronic kidney disease
- peritoneal dialysis
- young adults
- prognostic factors
- big data
- electronic health record
- machine learning
- methicillin resistant staphylococcus aureus
- combination therapy
- deep learning
- artificial intelligence
- staphylococcus aureus
- data analysis