Lung injury is induced by abrupt increase in respiratory rate but prevented by recruitment maneuver in mild acute respiratory distress syndrome in rats.
Paulo Henrique XavierAna Carolina Fernandes FonsecaLeonardo Alves GonçalvesGiselle Carvalho de SousaMariana Coelho da SilvaRaquel Ferreira de Magalhães SacramentoCynthia Dos Santos SamaryMayck MedeirosFernanda Ferreira CruzVera Luiza CapelozziNathane Santanna FelixPaolo PelosiJohn J MariniPatrícia Rieken Macêdo RoccoPedro Leme SilvaPublished in: Anesthesiology (2022)
In mild experimental ARDS in rats, gradually increasing RR, compared with abruptly doing so, can mitigate the development of VILI. In addition, recruitment maneuver prevented the injurious biological impact of abrupt increases in RR.