Assessment of NB-UVB Effects on Skin of Atopic Dermatitis Patients: A Network Analysis.
Mostafa Rezaei TaviraniFatemeh BandarianFarideh RaziZahra RazzaghiBabak ArjmandMohammad Rostami NejadPublished in: Journal of lasers in medical sciences (2024)
Introduction: Atopic dermatitis is a common inflammatory skin disease which is treated with narrowband ultraviolet B (NB-UVB). Exploring the critical targeted genes in patients by UV radiation is the main aim of this study. Methods: Gene expression profiles of lesional and non-lesional skin samples of atopic dermatitis patients after treatment with NB-UVB and the non-irradiated samples were extracted from the Gene Expression Omnibus (GEO) database and analyzed via protein-protein interaction (PPI) network analysis to find the critical targeted genes. Results: A total of 357 significant differentially expressed genes (DEGs) were included in the PPI network. CTNNB1, SRSF1, YWHAB, SMC3, GNB2, ARF3, UBL7, RAB2A, YWHAE, EIF5B, SNRPE, PPIG, RC3H2, CFL1, SMARCB1. LAPTM5, PRPF40A, and RBBP4 were introduced as hub-bottlenecks. Conclusion: In conclusion, five central genes including SMC3, ARF3, EIF5B, SMARCB1, and LAPTM5 were highlighted as the critical genes in response to NB-UVB radiation in the skin of the treated atopic dermatitis patients. The introduced crucial genes are involved in essential cellular functions such as apoptosis, cell cycle, cell proliferation, and inflammation. It seems that applied NB-UVB radiation is a suitable therapeutic method for atopic dermatitis disease.
Keyphrases
- atopic dermatitis
- end stage renal disease
- cell proliferation
- newly diagnosed
- ejection fraction
- cell cycle
- network analysis
- gene expression
- genome wide
- chronic kidney disease
- oxidative stress
- emergency department
- prognostic factors
- dna methylation
- peritoneal dialysis
- genome wide identification
- bioinformatics analysis
- drug delivery
- cell death
- signaling pathway
- patient reported outcomes
- cancer therapy
- radiation induced
- cell cycle arrest