Magneto-Electrically Enhanced Intracellular Catalysis of FePt-FeC Heterostructures for Chemodynamic Therapy.
Huilin ZhangJinjin LiYang ChenJiyue WuKun WangLijie ChenYa WangXingwu JiangYanyan LiuYelin WuDayong JinWen-Bo BuPublished in: Advanced materials (Deerfield Beach, Fla.) (2021)
Intracellular catalytic reactions can tailor tumor cell plasticity toward high-efficiency treatments, but the application is hindered by the low efficiency of intracellular catalysis. Here, a magneto-electronic approach is developed for efficient intracellular catalysis by inducing eddy currents of FePt-FeC heterostructures in mild alternating magnetic fields (frequency of f = 96 kHz and amplitude of B ≤ 70 mT). Finite element simulation shows a high density of induced charges gathering at the interface of FePt-FeC heterostructure in the alternating magnetic field. As a result, the concentration of an essential coenzyme-β-nicotinamide adenine dinucleotide-in cancer cells is significantly reduced by the enhanced catalytic hydrogenation reaction of FePt-FeC heterostructures under alternating magnetic stimulation, leading to over 80% of senescent cancer cells-a vulnerable phenotype that facilitates further treatment. It is further demonstrated that senescent cancer cells can be efficiently killed by the chemodynamic therapy based on the enhanced Fenton-like reaction. By promoting intracellular catalytic reactions in tumors, this approach may enable precise catalytic tumor treatment.
Keyphrases
- high density
- reactive oxygen species
- high efficiency
- finite element
- molecularly imprinted
- crystal structure
- stem cells
- wastewater treatment
- high glucose
- mesenchymal stem cells
- endothelial cells
- high resolution
- combination therapy
- mass spectrometry
- visible light
- replacement therapy
- smoking cessation
- functional connectivity