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Targeting AKR1B1 inhibits glutathione de novo synthesis to overcome acquired resistance to EGFR-targeted therapy in lung cancer.

Ke-Ren ZhangYu-Fei ZhangHui-Min LeiYa-Bin TangChun-Shuang MaQian-Ming LvShi-Yi WangLi-Ming LuYing ShenHong-Zhuan ChenLiang Zhu
Published in: Science translational medicine (2021)
[Figure: see text].
Keyphrases
  • small cell lung cancer
  • epidermal growth factor receptor
  • tyrosine kinase
  • cancer therapy
  • smoking cessation
  • drug delivery