Loss of H3K27 Trimethylation Promotes Radiotherapy Resistance in Medulloblastoma and Induces an Actionable Vulnerability to BET Inhibition.

Nishanth GabrielKumaresh BalajiKay Jayachandran Matthew J Inkman Jin Zhang Sonika M Dahiya Michael Goldstein

Published in: Cancer research (2022)

This study demonstrates a novel epigenetic mechanism of radiation resistance in medulloblastoma and identifies a therapeutic approach to improve outcomes in these patients.

Keyphrases

end stage renal disease
ejection fraction
chronic kidney disease
newly diagnosed
early stage
dna methylation
radiation therapy
radiation induced
locally advanced
adipose tissue