Loss of H3K27 Trimethylation Promotes Radiotherapy Resistance in Medulloblastoma and Induces an Actionable Vulnerability to BET Inhibition.
Nishanth GabrielKumaresh BalajiKay JayachandranMatthew J InkmanJin ZhangSonika M DahiyaMichael GoldsteinPublished in: Cancer research (2022)
This study demonstrates a novel epigenetic mechanism of radiation resistance in medulloblastoma and identifies a therapeutic approach to improve outcomes in these patients.