Adult-onset CNS myelin sulfatide deficiency is sufficient to cause Alzheimer's disease-like neuroinflammation and cognitive impairment.

Shulan QiuJuan Pablo PalaviciniJianing WangNancy S GonzalezSijia HeElizabeth DustinCheng ZouLin DingAnindita BhattacharjeeCandice E Van SkikeVeronica GalvanJeffrey L DupreeXianlin Han

Published in: Molecular neurodegeneration (2021)

Our results strongly suggest that sulfatide deficiency is an important contributor and driver of neuroinflammation and mild cognitive impairment in AD pathology.

Keyphrases

mild cognitive impairment
cognitive impairment
cognitive decline
lipopolysaccharide induced
traumatic brain injury
lps induced
replacement therapy
blood brain barrier
white matter
inflammatory response
multiple sclerosis
brain injury
smoking cessation