Myconanoparticles Break Antibiotic Resistance in Staphylococcus aureus and Acinetobacter baumannii.
S JanarthananS RanjaniHemalatha SPublished in: Applied biochemistry and biotechnology (2022)
In this current study, the extracts of endophytic fungi (Aspergillus niger) were utilized to synthesize the silver nanoparticles (AnNps). In silico screening was carried out by docking secondary metabolites of Aspergillus niger with drug-resistant proteins such as penicillin-binding protein (pbp2a) and clumping factor A of Staphylococcus aureus, penicillin-binding protein (PBP3), and outer membrane protein of Acinetobacter baumannii. The molecular docking analysis revealed the interaction between secondary metabolites of Aspergillus niger with virulence factors of the pathogenic bacteria. AnNps are characterized by various physicochemical methods to determine the size, shape, and stability. Antibacterial efficacy of synthesized nanoparticles (AnNps) was screened in clinical pathogens. AnNp treatment significantly reduced the growth of MDR pathogens. The results suggested that AnNps can be incorporated to produce antimicrobial agents to control drug resistant pathogenic bacteria.
Keyphrases
- drug resistant
- acinetobacter baumannii
- staphylococcus aureus
- molecular docking
- multidrug resistant
- silver nanoparticles
- gram negative
- binding protein
- molecular dynamics simulations
- biofilm formation
- cell wall
- ms ms
- methicillin resistant staphylococcus aureus
- antimicrobial resistance
- pseudomonas aeruginosa
- escherichia coli
- protein protein
- single cell
- combination therapy
- small molecule
- walled carbon nanotubes
- anti inflammatory