Frameshift Mutations in Leukemia-Associated Genes Correlate With Superior Outcomes in Patients Undergoing Allogeneic Stem Cell Transplant for De Novo Acute Myeloid Leukemia.
Emma CammannSindha MadhavLloyd HutchinsonJan CernyMuthalagu RamanathanJacob R BledsoeVladislav MakarenkoShyam A PatelXiuling MengKeith TomaszewiczRajneesh NathBenjamin ChenBruce WodaWilliam SelovePublished in: Journal of hematology (2024)
Our findings suggest that FS-mutated AML cases may benefit more from allo-SCT than those with only non-FS mutations, possibly due to increased generation of immunogenic neoepitopes. If validated in an expanded study, incorporation of somatic FS mutation status in AML could improve patient selection algorithms for bone marrow transplant and thereby lead to superior outcomes.
Keyphrases
- acute myeloid leukemia
- bone marrow
- stem cells
- patients undergoing
- allogeneic hematopoietic stem cell transplantation
- stem cell transplantation
- machine learning
- mesenchymal stem cells
- case report
- deep learning
- type diabetes
- dna methylation
- adipose tissue
- acute lymphoblastic leukemia
- low dose
- high dose
- insulin resistance
- skeletal muscle