Development of pyrazole derivatives in the management of inflammation.
Larissa Córdova TuronesAline Nazareth MartinsLorrane Kelle da Silva MoreiraJames Oluwagbamigbe FajemiroyeElson Alves CostaPublished in: Fundamental & clinical pharmacology (2020)
The therapeutic limitations and poor management of inflammatory conditions are anticipated to impact patients negatively over the coming decades. Following the synthesis of the first pyrazole-antipyrine in 1887, several other derivatives have been screened for anti-inflammatory, analgesic, and antipyretic activities. Arguably, the pyrazole ring, as a major pharmacophore and central scaffold partly, defines the pharmacological profile of several derivatives. In this review, we explore the structural-activity relationship that accounts for the pharmacological profile of pyrazole derivatives and highlights future research perspectives capable of optimizing current advancement in the search for safe and efficacy anti-inflammatory drugs. The flourishing research into the pyrazole derivatives as drug candidates has advanced our understanding of inflammation-related diseases and treatment.
Keyphrases
- molecular docking
- oxidative stress
- anti inflammatory
- molecular dynamics simulations
- structure activity relationship
- anti inflammatory drugs
- end stage renal disease
- ejection fraction
- newly diagnosed
- prognostic factors
- emergency department
- molecular dynamics
- neuropathic pain
- patient reported outcomes
- replacement therapy
- electronic health record