Evaluation of the MC4R gene across eMERGE network identifies many unreported obesity-associated variants.

Bahram NamjouIan B StanawayTodd LingrenFrank D MentchBarbara BenoitOzan DikilitasXinnan NiuNing ShangAshley H ShoemakerDavid J CareyTooraj MirshahiRajbir SinghJordan Gabriela NestorHakon HakonarsonJoshua C DennyDavid R CrosslinGail P JarvikIftikhar J KulloMarc S Williamsnull nullJohn B Harley

Published in: International journal of obesity (2005) (2020)

MC4R screening in a large eMERGE cohort confirmed many previous findings, extend the MC4R pleotropic effects, and discovered additional MC4R rare alleles that probably contribute to obesity.

Keyphrases

insulin resistance
metabolic syndrome
weight loss
copy number
type diabetes
genome wide
high fat diet induced
weight gain
adipose tissue
dna methylation
network analysis