Shifts in renin-angiotensin system components, angiogenesis, and oxidative stress-related protein expression in the lamina cribrosa region of streptozotocin-induced diabetic mice.
Xiaobing QianLeilei LinYao ZongYongguang YuanYanmin DongYue FuWanwen ShaoYujie LiQianying GaoPublished in: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie (2018)
Collectively, ACE 1, AT1R, HIF-1α, VEGF, VEGFR2, and HO-1 activation in the LC region in diabetic mice may be involved in diabetes via the RAS and induction of angiogenesis and oxidative stress.
Keyphrases
- diabetic rats
- oxidative stress
- vascular endothelial growth factor
- endothelial cells
- high glucose
- type diabetes
- dna damage
- ischemia reperfusion injury
- cardiovascular disease
- induced apoptosis
- angiotensin ii
- glycemic control
- adipose tissue
- high fat diet
- metabolic syndrome
- cell proliferation
- simultaneous determination
- drug induced