Psidium cattleianum fruit extract prevents systemic alterations in an animal model of type 2 Diabetes Mellitus: comparison with metformin effects.
Juliane deSouza CardosoFernanda Cardoso TeixeiraJulia Eisenhardt de MelloMayara Sandrielly Soares de AguiarPathise Souto OliveiraJuliane Torchelsen SaraivaMarcia VizzottoFabiane Borelli GreccoClaiton Leoneti LencinaRoselia Maria SpanevelloRejane Giacomelli TavaresFrancieli Moro StefanelloPublished in: Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals (2022)
Objective: In this study, we aimed to determine the role of Psidium cattleianum extract (PCE) and compare its effects with those of metformin (Met) in an animal model with type 2 diabetes mellitus (T2DM). Methods: T2DM was induced in rats using a high-fat diet (HFD), followed by a single dose of streptozotocin (STZ). Met and PCE were administered intragastrically once a day throughout the experiment, and their effects on biochemical, inflammatory, oxidative, and histological parameters were evaluated. Results: Met and PCE prevented the increase in serum levels of glucose, total cholesterol (TC), triacylglycerol (TG), very low-density lipoprotein (VLDL) and interleukin-6 (IL-6) induced by T2DM, and restored redox homeostasis in the liver and brain. Met increased the serum levels of anti-inflammatory cytokine and interleukin-10 (IL-10). Furthermore, both treatments restored the liver and pancreas from marked cellular disorganization, vacuolization, and necrosis, with PCE being more effective than Met in recovering histological changes. Conclusion: PCE is a promising agent for the prevention of T2DM complications.