Potential role of circulating miR-21 in the diagnosis of hepatocellular carcinoma: a systematic review and meta-analysis.

Ana Karla da Silva FreireTaciana Furtado de Mendonça BelmontEdgo Jackson Pinto SantiagoIsabela Cristina Cordeiro FariasKleyton Palmeira do ÓAndreia Soares da SilvaLuydson Richardson Silva Vasconcelos

Published in: Expert review of molecular diagnostics (2022)

miR-21 has a moderate overall performance in diagnosing HCC and may serve as a potential non-invasive marker for this early-stage disease. Thus, it may contribute to complementing the results of alpha-fetoprotein in the diagnosis and help to detect HCC at an earlier stage, increasing the survival chances of these patients.

Keyphrases

early stage
cell proliferation
long non coding rna
end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
prognostic factors
high intensity