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Physiologically based pharmacokinetic evaluation of cefuroxime in perioperative antibiotic prophylaxis.

Christer RimmlerChristian LanckohrCeren AkampDagmar HornManfred FobkerKarsten WiebeBassam RedwanBjoern EllgerRobin KoeckGeorg Hempel
Published in: British journal of clinical pharmacology (2019)
The use of cefuroxime for perioperative antibiotic prophylaxis to prevent staphylococcal surgical site infections appears to be effective with standard dosing of 1.5 g preoperatively and follow-up doses every 2.5 hours. In contrast, if E. coli is relevant in surgeries, this dosing regimen appears insufficient. With our derived dose recommendations, we provide a solution for this issue.
Keyphrases
  • cardiac surgery
  • patients undergoing
  • staphylococcus aureus
  • escherichia coli
  • magnetic resonance
  • acute kidney injury
  • clinical practice
  • computed tomography