Physiologically based pharmacokinetic evaluation of cefuroxime in perioperative antibiotic prophylaxis.
Christer RimmlerChristian LanckohrCeren AkampDagmar HornManfred FobkerKarsten WiebeBassam RedwanBjoern EllgerRobin KoeckGeorg HempelPublished in: British journal of clinical pharmacology (2019)
The use of cefuroxime for perioperative antibiotic prophylaxis to prevent staphylococcal surgical site infections appears to be effective with standard dosing of 1.5 g preoperatively and follow-up doses every 2.5 hours. In contrast, if E. coli is relevant in surgeries, this dosing regimen appears insufficient. With our derived dose recommendations, we provide a solution for this issue.