Characterization of BRCA1 and BRCA2 genetic variants in a cohort of Bahraini breast cancer patients using next-generation sequencing.

Fatima Al HannanMichael B KeoghSafa TahaLatifa Al Buainain

Published in: Molecular genetics & genomic medicine (2019)

Our data suggest that BRCA1/2 variants may contribute to the pathogenesis of familial breast cancer in Bahrain. It also shows that NGS is useful tool for screening BRCA1/2 genetic variants of probands and unaffected relatives.

Keyphrases

breast cancer risk
copy number
electronic health record
gene expression
early onset
big data
machine learning
genome wide
deep learning