Thermoregulatory profile of neurodegeneration-induced dementia of the Alzheimer's type using intracerebroventricular streptozotocin in rats.
A C P Motzko-SoaresR C L VizinT M S MartinsA R O HungaroJ R SatoMaria Camila AlmeidaDaniel C CarrettieroPublished in: Acta physiologica (Oxford, England) (2018)
Our data bring evidence that icv-STZ in rats causes hyperthermia, with activation of both autonomic and behavioural thermoregulatory defence responses when challenged at colder temperatures, leading us to hypothesize that they are more efficient in preventing hypothermia. These data are relevant for a better understanding of neurodegenerative disease mechanisms.
Keyphrases
- diabetic rats
- oxidative stress
- electronic health record
- big data
- mild cognitive impairment
- cardiac arrest
- high fat diet
- high glucose
- cognitive decline
- heart rate variability
- brain injury
- cognitive impairment
- heart rate
- machine learning
- artificial intelligence
- endothelial cells
- metabolic syndrome
- drug induced
- type diabetes
- blood pressure
- stress induced