CircADAMTS6/miR-431-5p axis regulate interleukin-1β induced chondrocyte apoptosis.

Qiwei FuLexiang LiBo WangJun WuHaobo LiYaguang HanDong XiangYi ChenJun Zhu

Published in: The journal of gene medicine (2021)

Our findings demonstrate that the circADAMTS6/miR-431-5p axis comprises a new target for OA. Bioinformatic analysis suggested that circADAMTS6 acted as a sponge of miR-431-5p.

Keyphrases

oxidative stress
diabetic rats
endoplasmic reticulum stress
high glucose
cell death
cell cycle arrest
drug induced
cell proliferation
signaling pathway