Network Pharmacology and Molecular Docking Analysis to Explore the Mechanism of Huaiqihuang-Mediated Alleviation of Henoch-Schönlein Purpura Nephritis.
Qingqing LiuJiahua LiuYa-Ya DuWeiyan GuoJie MiYan-Yan GuoPublished in: BioMed research international (2022)
The study preliminarily explored the active ingredients, targets, and pathways involved in HQH therapy for HSPN. The mechanism of HQH therapy may be attributed to the modulation of inflammatory response, immune response, and oxidative stress. Combined with clinical data, our results indicate that HQH is highly effective in treating HSPN.
Keyphrases
- molecular docking
- inflammatory response
- immune response
- oxidative stress
- molecular dynamics simulations
- lipopolysaccharide induced
- toll like receptor
- lps induced
- big data
- dendritic cells
- stem cells
- induced apoptosis
- mesenchymal stem cells
- deep learning
- signaling pathway
- data analysis
- diabetic rats
- bone marrow
- heat shock