Self-assembled lipoprotein based gold nanoparticles for detection and photothermal disaggregation of β-amyloid aggregates.

P A T MartinsS AlsaiariK JulfakyanZhihong Nie Niveen M Khashab

Published in: Chemical communications (Cambridge, England) (2018)

We present a reconstituted lipoprotein-based nanoparticle platform comprising a curcumin fluorescent motif and an NIR responsive gold core. This multifunctional nanosystem is successfully used for aggregation-dependent fluorescence detection and photothermal disassembly of insoluble amyloid aggregates.

Keyphrases

cancer therapy
photodynamic therapy
gold nanoparticles
drug delivery
label free
drug release
loop mediated isothermal amplification
real time pcr
low density lipoprotein
quantum dots
high throughput
fluorescence imaging
single molecule
living cells