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Growth, puberty and testicular function in boys born small for gestational age with a nonspecific disorder of sex development.

Lloyd J W TackSaskia van der StraatenStefan RiedlAlexander SpringerPaul-Martin HolterhusNadine C HornigZofia KolesinskaMarek NiedzielaFederico BaronioAntonio BalsamoSabine E HannemaAnna NordenströmŞükran PoyrazoğluFatma F DarendelilerRomina GrinsponRodolfo Alberto ReyFahad AljuraibahJillian BryceSyed Faisal AhmedRieko Tadokoro-CuccaroIeuan HughesGuilherme Guaragna-FilhoAndrea T Maciel-GuerraGil Guerra-JuniorMartine Cools
Published in: Clinical endocrinology (2021)
Almost one out of three SGA boys with a nonspecific DSD experiences insufficient catch-up growth. In addition, our data suggest dysfunction of infantile Leydig cells or altered regulation of the hypothalamic-pituitary-gonadal axis in SGA boys during childhood. Sex steroid production during puberty seems unaffected.
Keyphrases
  • gestational age
  • birth weight
  • preterm birth
  • induced apoptosis
  • oxidative stress
  • mental health
  • cell cycle arrest
  • low birth weight
  • big data
  • young adults
  • preterm infants
  • germ cell
  • data analysis