Copper coordination-based conjugated polymer nanoparticles for synergistic photodynamic and chemodynamic therapy.

In this work, we presented a copper coordination-based conjugated polymer nanoparticle (PPE-Cu NPs) for synergistic PDT/CDT. Upon irradiation, PPE-Cu NPs exhibited good singlet oxygen generation capability ( Φ Δ = 0.33). Meanwhile, PPE-Cu NPs were able to generate ˙OH in the presence of GSH and H 2 O 2 . Cellular experiments demonstrated that PPE-Cu NPs can serve as effective agents for synergistic PDT/CDT therapy.