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Arterial stiffening acts synergistically with APOE genotype and AD biomarker status to influence memory in older adults without dementia.

Katherine J BangenDenis S SmirnovLisa Delano-WoodChristina E WierengaMark W BondiDavid P SalmonDouglas Galasko
Published in: Alzheimer's research & therapy (2021)
The findings suggest that pulse wave velocity, a non-invasive method to assess arterial wall properties, may be a useful marker of risk for cognitive decline, particularly among individuals who are APOE ε4 carriers or CSF AD biomarke0r-positive.
Keyphrases
  • cognitive decline
  • mild cognitive impairment
  • blood pressure
  • physical activity
  • working memory
  • cognitive impairment
  • type diabetes
  • skeletal muscle
  • metabolic syndrome
  • insulin resistance
  • high fat diet