Catalytic Enantioselective [10+4] Cycloadditions.
Bjarke S DonslundNicolaj Inunnguaq JessenGiulio BertuzziMaxime GiardinettiTeresa A PalazzoMette Louise ChristensenKarl Anker JørgensenPublished in: Angewandte Chemie (International ed. in English) (2018)
The first peri- and stereoselective [10+4] cycloaddition between catalytically generated amino isobenzofulvenes and electron-deficient dienes is described. The highly stereoselective catalytic [10+4] cycloaddition exhibits a broad scope with high yields, reflecting a robust higher-order cycloaddition. Experimental and computational investigations support a kinetic distribution of intermediate rotamers dictating the enantioselectivity, which relies heavily on additive effects.
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