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Nintedanib allows retreatment with atezolizumab of combined non-small cell lung cancer/idiopathic pulmonary fibrosis after atezolizumab-induced pneumonitis: a case report.

Hideaki YamakawaTomohiro ObaHiroki OhtaYuta TsukaharaGen KidaEmiri TsumiyamaTomotaka NishizawaRie KawabeShintaro SatoKeiichi AkasakaMasako AmanoKazuyoshi KuwanoHidekazu Matsushima
Published in: BMC pulmonary medicine (2019)
This case indicates the possibility that the addition of nintedanib to ICI therapy might prevent drug-induced pneumonitis or acute exacerbation of IPF. However, whether anti-fibrotic agents such as nintedanib are actually effective in preventing ICI-induced pneumonitis in ILD remains unknown and additional research is greatly needed to identify effective therapies for ILD combined with lung cancer.
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