Cytokine-Mediated Degradation of the Transcription Factor ERG Impacts the Pulmonary Vascular Response to Systemic Inflammatory Challenge.
Christopher M SchaferSilvia Martin-AlmedinaKatarzyna KurylowiczNeil P DuftonLourdes Osuna-AlmagroMeng-Ling WuCharmain F JohnsonAarti V ShahDorian O HaskardAndrianna BuxtonErika WillisKate WheelerSean TurnerMagdalena ChlebiczRizaldy P ScottSusan KovatsAudrey CleurenGraeme M BirdseyAnna M RandiCourtney T GriffinPublished in: Arteriosclerosis, thrombosis, and vascular biology (2023)
Collectively, our data highlight a unique role for ERG in pulmonary vascular function. We propose that cytokine-induced ERG degradation and subsequent transcriptional changes in lung ECs play critical roles in the destabilization of pulmonary blood vessels during infectious diseases.