PIK3/Akt/mTOR pathway alterations in metastatic castration-sensitive prostate cancer.

Philip SuteraJongmyung KimRitesh KumarRebecca A DeekRyan StephensonTina MayerBiren SaraiyaSaum GhodoussipourThomas JangDavid GolombosVignesh PackiamRonald EnnisLara HathoutSalma K JabbourOzan GulerCem Onal Phuoc T Tran Matthew P Deek

Published in: The Prostate (2024)

PIK3/Akt/mTOR pathway alterations were common in mCSPC and associated with poorer prognosis. The genetic landscape of PIK3/Akt/mTOR pathway altered tumors differed from wildtype tumors. Additional studies are needed to better understand and target the PIK3/Akt/mTOR pathway in mCSPC.

Keyphrases

cell proliferation
prostate cancer
signaling pathway
squamous cell carcinoma
small cell lung cancer
genome wide
radical prostatectomy
dna methylation
copy number