Mucosa-associated invariant T cells link intestinal immunity with antibacterial immune defects in alcoholic liver disease.
Antonio RivaVishal PatelAyako KuriokaHannah C JefferyGavin WrightSarah TarffDebbie ShawcrossJennifer M RyanAlexander EvansSarah AzarianJasmohan S BajajAndrew FaganVinood PatelKosha MehtaCarlos LopezMarieta SimonovaKrum KatzarovTanya HadzhiolovaSlava PavlovaJulia A WendonYe Htun OoPaul KlenermanRoger WilliamsShilpa ChokshiPublished in: Gut (2017)
In ALD, the antibacterial potency of MAIT cells is compromised as a consequence of contact with microbial products and microbiota, suggesting that the 'leaky' gut observed in ALD drives MAIT cell dysfunction and susceptibility to infection in these patients.