Maternal liver transplant: Another cause of discordant fetal sex determination using cell-free DNA.

Maria C NeofytouNathalie BrisonKris Van den BogaertLuc DehaspeKoen DevriendtAnja GeertsJoris R Vermeesch

Published in: Prenatal diagnosis (2018)

Noninvasive prenatal testing (NIPT) can very accurately determine fetal sex during pregnancy. We present an exceptional case where NIPT contradicts the ultrasound-based sex determination. The pregnant woman was recipient of a liver transplant from a male donor. Graft-derived cell-free DNA released into the maternal circulation clouded the NIPT-based sex determination. Hence, NIPT is not advisable when the pregnant mother underwent an organ transplant.

Keyphrases

pregnant women
solid phase extraction
molecularly imprinted
birth weight
pregnancy outcomes
body mass index
mass spectrometry
preterm birth