Landscape of enhancer disruption and functional screen in melanoma cells.

Zhao WangMenghan LuoQian LiangKe ZhaoYuelin HuWei WangXiangling FengBolang HuJianjin TengTianyi YouRan LiZhengkai BaoWenhao PanTielong YangChao ZhangTing LiXiaobao DongXianfu YiBen LiuLi ZhaoMiaoxin LiKexin ChenWeihong SongJilong YangMulin Jun Li

Published in: Genome biology (2023)

Our study establishes a catalogue of crucial enhancers and their target genes in melanoma growth and progression, and illuminates the identification of novel mechanisms of dysregulation for melanoma driver genes and new therapeutic targeting strategies.

Keyphrases

bioinformatics analysis
genome wide
skin cancer
high throughput
transcription factor
binding protein
single cell
basal cell carcinoma
gene expression
dna methylation
cancer therapy