CSF neopterin and quinolinic acid are biomarkers of neuroinflammation and neurotoxicity in FIRES and other infection-triggered encephalopathy syndromes.

Russell C DaleTerrence ThomasShrujna PatelVelda X HanKavitha KothurChristopher TroedsonSachin GuptaDeepak GillStephen MaloneMichaela WaakSophie CalvertGopinath SubramanianP Ian AndrewsTejaswi KandulaManoj P MenezesSimone Ardern-HolmesShekeeb MohammadSushil BandodkarJingya Yan

Published in: Annals of clinical and translational neurology (2023)

CSF neopterin and quinolinic acid are neuroinflammatory and excitotoxic metabolites. This CSF metabolomic inflammatory panel can discriminate ITES from other causes of new onset seizures or status epilepticus, and rapid results (4 h) may facilitate early immune modulatory therapy.

Keyphrases

traumatic brain injury
ms ms
cerebrospinal fluid
oxidative stress
early onset
lps induced
lipopolysaccharide induced
cognitive impairment
inflammatory response
loop mediated isothermal amplification