Black Phosphorus: Bioactive Nanomaterials with Inherent and Selective Chemotherapeutic Effects.
Wenhua ZhouTing PanHaodong CuiZhen ZhaoPaul K ChuXue-Feng YuPublished in: Angewandte Chemie (International ed. in English) (2018)
Black phosphorus nanosheets (BPs) are demonstrated to be highly bioactive anti-cancer agents because of their inherent and selective chemotherapeutic effects. Fast intracellular biodegradation of BPs and acute elevation of phosphate anions were observed from different types of cancer cells due to the stronger intracellular oxidative stress and accelerated energy metabolism, but normal cells are not affected. Selective biodegradation of BPs induced G2/M phase arrest and subsequent apoptosis- and autophagy-mediated cell death in cancer cells but not normal cells. The selectivity was superior to that of the traditional chemotherapeutic agent, doxorubicin (DOX). In vivo assessment confirmed the efficiency of BPs in suppressing tumor growth. This study provides insights into nanostructured bioactive anti-cancer agents and reveals a new direction for nanomedicine research.
Keyphrases
- cell cycle arrest
- cell death
- induced apoptosis
- oxidative stress
- endoplasmic reticulum stress
- signaling pathway
- pi k akt
- diabetic rats
- drug induced
- cancer therapy
- liver failure
- reactive oxygen species
- ischemia reperfusion injury
- intensive care unit
- high glucose
- respiratory failure
- ionic liquid
- risk assessment
- hepatitis b virus
- gold nanoparticles
- mechanical ventilation
- anaerobic digestion