The PKA-CREB1 axis regulates coronavirus proliferation by viral helicase nsp13 association.
Tong ZhengBeilei ShenYu BaiEntao LiXun ZhangYong HuTing GaoQincai DongLin ZhuRui JinHui ShiHainan LiuYuwei GaoXuan LiuCheng CaoPublished in: Journal of virology (2024)
. Notably, the IC50 of CREB1 inhibitor 666-15 is comparable to that of remdesivir. These results may extend to all highly pathogenic coronaviruses due to the conserved nsp13 sequences in the virus.