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Immunosurveillance profile of oral squamous cell carcinoma and oral epithelial dysplasia through dendritic and T-cell analysis.

Ana Carolina Amorim PellicioliLynne BinglePaula FarthingMárcio Ajudarte LopesManoela Domingues MartinsPablo Agustin Vargas
Published in: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology (2017)
The number of mature dendritic cells (DC) was decreased in OSCC compared with OED lesions suggesting that either these cells might have migrated to lymph nodes to present the tumour antigens and activate the immune system or cytokines secreted by the tumour microenvironment are inhibiting the adequate maturation of DLC. The numbers of pDC were significantly increased in the OSCC group compared with the OED group. This suggests they may play an important role in the defence against tumours although it is not clear whether this is promoting or inhibiting malignant progression.
Keyphrases
  • dendritic cells
  • lymph node
  • induced apoptosis
  • signaling pathway
  • regulatory t cells
  • immune response
  • cell cycle arrest
  • stem cells
  • endoplasmic reticulum stress
  • cell death