Estimates of all cause mortality and cause specific mortality associated with proton pump inhibitors among US veterans: cohort study.
Yan XieBenjamin BoweYan YanHong XianTingting LiZiyad Al-AlyPublished in: BMJ (Clinical research ed.) (2019)
Taking PPIs is associated with a small excess of cause specific mortality including death due to cardiovascular disease, chronic kidney disease, and upper gastrointestinal cancer. The burden was also observed in patients without an indication for PPI use. Heightened vigilance in the use of PPI may be warranted.