Suppression of histone deacetylases by SAHA relieves bone cancer pain in rats via inhibiting activation of glial cells in spinal dorsal horn and dorsal root ganglia.
Xiao-Tao HeXiao-Fan HuChao ZhuKai-Xiang ZhouWen-Jun ZhaoChen ZhangXiao HanChang-Le WuYan-Yan WeiWei WangJian-Ping DengFa-Ming ChenZe-Xu GuYu-Lin DongPublished in: Journal of neuroinflammation (2020)
Our findings suggest that HDAC1 and HDAC2 are involved in the glia-mediated neuroinflammation in the spinal dorsal horn and dorsal root ganglia underlying the pathogenesis of BCP, which indicated that inhibiting HDACs by SAHA might be a potential strategy for pain relief of BCP.
Keyphrases
- neuropathic pain
- spinal cord
- histone deacetylase
- spinal cord injury
- induced apoptosis
- signaling pathway
- dna methylation
- papillary thyroid
- traumatic brain injury
- cell cycle arrest
- chronic pain
- lipopolysaccharide induced
- young adults
- oxidative stress
- blood brain barrier
- body composition
- squamous cell
- pain management
- climate change
- lymph node metastasis
- human health