Deficiency in insulin-like growth factors signalling in mouse Leydig cells increase conversion of testosterone to estradiol because of feminization.

Sava M Radovic PletikosicIsidora M StarovlahDejan MiljkovicDragana M BajicIvan CapoSerge NefTatjana S Kostic Silvana A Andric

Published in: Acta physiologica (Oxford, England) (2020)

The results provide new molecular mechanisms leading to the development of the female phenotype in Leydig cells from Insr/Igf1r-DKO mice and could help to better understand the correlation between insulin resistance, testosterone and male (in)fertility.

Keyphrases

replacement therapy
insulin resistance
type diabetes
high fat diet induced
induced apoptosis
cell cycle arrest
adipose tissue
glycemic control
metabolic syndrome
high fat diet
pi k akt
skeletal muscle
endoplasmic reticulum stress
estrogen receptor
binding protein
growth hormone
cell proliferation