Effects of acute sleep loss on diurnal plasma dynamics of CNS health biomarkers in young men.
Christian BenedictKaj BlennowHenrik ZetterbergJonathan CedernaesPublished in: Neurology (2020)
Our exploratory study suggests that acute sleep loss results in increased blood levels of t-tau. These changes provide further evidence that sleep loss may have detrimental effects on brain health even in younger individuals. Larger cohorts are warranted to delineate sleep vs circadian mechanisms, implications for long-term recurrent conditions (e.g., in shift workers), as well as interactions with other lifestyle and genetic factors.
Keyphrases
- physical activity
- sleep quality
- liver failure
- healthcare
- public health
- mental health
- respiratory failure
- cardiovascular disease
- metabolic syndrome
- health information
- drug induced
- gene expression
- weight loss
- risk assessment
- hepatitis b virus
- genome wide
- white matter
- dna methylation
- human health
- acute respiratory distress syndrome
- cerebral ischemia