Spatially informed gene signatures for response to immunotherapy in melanoma.

Thazin Nwe Aung Jonathan Warrell Sandra Martinez-Morilla Niki Gavrielatou Ioannis A Vathiotis Vesal Yaghoobi Harriet M Kluger Mark B Gerstein David L Rimm

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)

We conclude that the spatially defined compartment signatures utilize tumor and TME-specific information, leading to more accurate prediction of treatment outcome, and thus merit prospective clinical assessment.

Keyphrases

genome wide
copy number
dna methylation
high resolution
health information
healthcare
mass spectrometry
genome wide analysis