Role of hydroxymethylglutharyl-coenzyme A reductase in the induction of stem-like states in breast cancer.

María Paula MarksCarla Alejandra GiménezLuciana IsajaMariana Belén VeraFrancisco Raúl BorzoneFederico Pereyra-BonnetLeonardo RomoriniGuillermo Agustín Videla-RichardsonNorma Alejandra ChasseingJuan Carlos CalvoLuciano Vellon

Published in: Journal of cancer research and clinical oncology (2024)

HMGCR induces a stem-like phenotype in BC cells of epithelial nature, thus affecting tumor initiation, progression and statin sensitivity.

Keyphrases

induced apoptosis
cell cycle arrest
cardiovascular disease
coronary artery disease
endoplasmic reticulum stress
cell death
signaling pathway
oxidative stress
young adults