Eosinophil cytolysis on Immunoglobulin G is associated with microtubule formation and suppression of rho-associated protein kinase signalling.
Stephane EsnaultJonathan P LeetMats W JohanssonKarina T BarrettoPaul S FichtingerFrances J FogertyKsenija BernauSameer K MathurDeane F MosherNathan SandboNizar N JarjourPublished in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2019)
In this CD32- and αMß2 integrin-dependent adhesion model, lysing eosinophils exhibit reduced migration and ROCK signalling, as well as both MT dynamic changes and p-38 phosphorylation downstream of ROS production. We propose that interfering with these pathways would modulate eosinophil cytolysis and subsequent eosinophil-driven tissue damage.