Is the blood of a surgeon performing HIPEC contaminated by irinotecan, its major metabolites and platinum compounds?
Guillaume Saint-LorantSimon RodierJean-Marc GuilloitSophie NdawMathieu MelczerStéphanie LagaduAgnès PalixRaphaël DelépéePublished in: Pleura and peritoneum (2021)
Even if this study shows blood contamination by irinotecan, two of its major metabolites (including active SN-38) and platinum compounds both in the plasma and RBC of a surgeon performing the HIPEC procedures, further studies should be performed to confirm these results. Additional studies should be carried out to further investigate the contamination in the context of HIPEC and more broadly in the hospital.