Incidence and risk factors of early HCC occurrence in HCV patients treated with direct acting antivirals: a prospective multicentre study.

Luca RinaldiAlessandro PerrellaMaria GuarinoMassimo De LucaGuido PiaiNicola CoppolaPia Clara PafundiFortunato CiardielloMorena FasanoErika MartinelliGiovanna ValenteRiccardo NevolaCaterina MonariLucia MiglioresiBarbara GuerreraMassimiliano BerrettaFerdinando Carlo SassoFilomena MoriscoAntonio IzziLuigi Elio Adinolfi

Published in: Journal of translational medicine (2019)

Our data suggest that early HCC occurrence appears more frequently related to Sofosbuvir-based therapy without Ribavirin which, indeed, seems to play a protective role on HCC onset. Therefore, a careful follow-up should be mandatory, especially in those regimens including Sofosbuvir without Ribavirin.

Keyphrases

hepatitis c virus
risk assessment
human immunodeficiency virus
hepatitis c virus infection
electronic health record
big data
stem cells
machine learning
cell therapy