Diurnal Variability of Platelet Aggregation in Patients with Myocardial Infarction Treated with Prasugrel and Ticagrelor.
Jacek KubicaMalwina BarańskaMałgorzata OstrowskaWiktor KuliczkowskiKatarzyna BuszkoKatarzyna Kościelska-KasprzakBożena KarolkoAndrzej MysiakJacek KubicaPublished in: Journal of clinical medicine (2022)
Ticagrelor shows greater diurnal variability in platelet aggregation than prasugrel during the initial maintenance phase of AMI treatment, and this is due to the continuous increase of platelet inhibition after the morning maintenance dose. Both drugs provide an adequate antiplatelet effect early after AMI. Evaluation of the clinical significance of these findings warrants further investigation.
Keyphrases
- percutaneous coronary intervention
- acute myocardial infarction
- acute coronary syndrome
- st segment elevation myocardial infarction
- st elevation myocardial infarction
- antiplatelet therapy
- coronary artery disease
- heart failure
- left ventricular
- atrial fibrillation
- combination therapy
- replacement therapy
- drug induced