Screening of Fabry Disease in Patients with Chest Pain Without Obstructive Coronary Artery Disease.
Aitor Hernández-HernándezCarles Diez-LópezOlga AzevedoJulian Palomino-DozaFernando AlfonsoMaría Eugenia Fuentes-CañameroMaría Victoria Mogollón JiménezCarlos Casanova RodríguezAurora RuzColoma TirónVicente ClimentPablo García-PavíaPublished in: Journal of cardiovascular translational research (2021)
Identification of Anderson-Fabry disease (AFD) in cardiac patients has been restricted so far to patients with left ventricular hypertrophy. Coronary microvascular dysfunction has been described in AFD with and without cardiac hypertrophy and may represent the only manifestation in AFD patients, offering a possible earlier diagnosis. We studied the prevalence of AFD in 663 patients with chest pain with normal or non-obstructive coronary arteries. The overall prevalence of AFD in this cohort was only 0.15% (1/663). AFD is not a frequent cause of chest pain without obstructive coronary artery disease and screening efforts should not be conducted in this patient population.
Keyphrases
- coronary artery disease
- end stage renal disease
- left ventricular
- newly diagnosed
- ejection fraction
- chronic kidney disease
- coronary artery
- aortic stenosis
- heart failure
- percutaneous coronary intervention
- peritoneal dialysis
- hypertrophic cardiomyopathy
- cardiovascular disease
- coronary artery bypass grafting
- patient reported outcomes
- atrial fibrillation
- replacement therapy
- acute myocardial infarction
- quality improvement
- acute coronary syndrome
- transcatheter aortic valve replacement
- left atrial