Deficiency of Peptidylglycine-alpha-amidating Monooxygenase, a Cause of Sarcopenic Diabetes Mellitus.

Alice GiontellaMikael ÅkerlundKevin BrontonCristiano FavaLuca A LottaAris BarasJohn D OvertonMarcus JonesAndreas BergmannPaul KaufmannYulia IlinaOlle Melander

Published in: The Journal of clinical endocrinology and metabolism (2024)

PAM-AMA genetic deficiency results in a prediabetic sarcopenic phenotype. Early identification of PAM LoF carriers would allow targeted exercise interventions and calls for novel therapies that restore enzymatic activity.

Keyphrases

physical activity
replacement therapy
high intensity
hydrogen peroxide
cancer therapy
resistance training
type diabetes
copy number
dna methylation
adipose tissue
body composition
weight loss