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Reflex BRCA1 and BRCA2 tumour genetic testing for high-grade serous ovarian cancer: streamlined for clinicians but what do patients think?

Jeanna M McCuaigSarah E FergusonDanielle VicusKaren OttTracy L StockleyRaymond H KimKelly A Metcalfe
Published in: Hereditary cancer in clinical practice (2022)
This study is the first to assess psychological outcomes following reflex BRCA1/2 tumour genetic testing in women newly diagnosed with HGSOC. Increased dispositional optimism provided a protective effect, while increased cancer-related distress increased the psychological impact of tumour genetic testing. Educational resources are needed to help increase patient understanding and recall of tumour results, particularly when tumour genetic testing includes analysis of genes that may have implications for hereditary cancer risk. Additional research is required to better understand the patient experience of reflex tumour genetic testing.
Keyphrases
  • newly diagnosed
  • high grade
  • low grade
  • palliative care
  • breast cancer risk
  • polycystic ovary syndrome
  • dna methylation
  • adipose tissue
  • patient reported
  • pregnancy outcomes