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Exploring molecular mechanisms of intra-articular changes in osteonecrosis of femoral head using DIA proteomics and bioinformatics.

Gang ZhaoYujie LiuYongjun ZhengMingyang AnJia ZhangJing ZhangZhongli LiChunbao Li
Published in: Journal of orthopaedic surgery and research (2024)
With DIA proteomics and bioinformatics analysis, this study reveals the molecular mechanisms of intra-articular lesions in ONFH. A correlation in the necrotic area and load-bearing cartilage of ONFH at ARCO stages IIIB-IV as well as potential key regulatory proteins was identified. These findings will help more deeply understand the pathogenesis of ONFH and may provide important clues for seeking more effective treatment strategies.
Keyphrases
  • bioinformatics analysis
  • mass spectrometry
  • label free
  • mental health
  • transcription factor
  • extracellular matrix
  • human health