Mesoporous silica nanoparticles inflame tumors to overcome anti-PD-1 resistance through TLR4-NFκB axis.

Mayu SunPengfei GuYang YangLuodan YuZheshun JiangJingquan LiYingying LeYu ChenQian BaHui Wang

Published in: Journal for immunotherapy of cancer (2022)

MSNs efficiently and rapidly inflame immunologically cold tumors and resensitize them to anti-PD-1 therapy through TLR4-NFκB-Ccl5/Cxcl9/Cxcl10 axis. MSNs-based theranostic agents can serve as sensitizers for patients with resistant tumors to improve immunotherapy.

Keyphrases

nuclear factor
toll like receptor
inflammatory response
signaling pathway
lps induced
immune response
oxidative stress
pi k akt
photodynamic therapy
stem cells
liver injury
bone marrow
liver fibrosis
drug induced
solar cells
iron oxide