A Prodromal Brain-Clinical Pattern of Cognition in Synucleinopathies.

Shady RahayelRonald B PostumaJacques MontplaisirBratislav MišićChristina TremblayAndrew VoSimon LewisElie MatarKaylena Ehgoetz MartensFrédéric BlancChun YaoJulie CarrierOury MonchiMalo GaubertAlain DagherJean-François Gagnon

Published in: Annals of neurology (2020)

We identified a brain-clinical signature that predicts conversion in iRBD to more severe/dementing forms of synucleinopathy. This pattern may serve as a new biomarker to optimize patient care, target risk reduction strategies, and administer neuroprotective trials. ANN NEUROL 2021;89:341-357.

Keyphrases

white matter
cerebral ischemia
resting state
functional connectivity
multiple sclerosis
mild cognitive impairment
early onset
brain injury
deep brain stimulation